Aug 18, 2023

Uncombable Hair Syndrome: Temporary Symptoms in Kids

Uncombable hair syndrome is a rare medical condition that causes the hair on the scalp to grow up and out instead of downward. People with this condition can't comb or brush their hair flat. Their hair may appear frizzy, coarse, or "wooly." It's typically white or the color of light straw.

Uncombable hair syndrome typically affects babies and children. It usually resolves on its own over time. The condition is very rare, with just 100 documented cases worldwide.

Uncombable hair syndrome also goes by several other names, including:

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Most cases of uncombable hair syndrome are caused by mutations in the PADI3, TGM3, or TCHH genes. These genetic variations alter the shape of the hair shaft, causing the cross-sections to become triangle-, heart-, or kidney-shaped. This affects how the strands of hair can grow and lay on the head. To be diagnosed with uncombable hair syndrome, at least half of a child's strands of hair must be abnormally shaped.

Some people with uncombable hair syndrome also have comorbid conditions, such as:

Uncombable hair syndrome causes hair to have a distinct appearance, color, and texture. Telltale signs of the condition include:

People with uncombable hair syndrome don't tend to have brittle, fragile, or easily breakable hair. The strands of hair also tend to grow at a typical rate.

There's no specific treatment for uncombable hair syndrome. Some case studies indicate that biotin supplements may help, but the findings are inconclusive.

Outside of practicing patience—since most cases go away on their own over time—uncombable hair syndrome can primarily be addressed with hair care. Parents of kids with uncombable hair syndrome may find the following hair care tips useful:

If you’re still having trouble, consider talking to a dermatologist (a specialist in conditions of the skin, hair, and nails) or another healthcare provider about how best to care for your child's hair. They may be able to offer more targeted advice, based on your child's specific hair texture.

Usually, uncombable hair syndrome first appears in infancy or early childhood (before age 3). In some cases, the signs may not show up until age 12.

It's not entirely clear why, but uncombable hair syndrome often improves on its own during late childhood and early adolescence. Most people with the condition no longer experience symptoms once they reach their preteen years. Then, they’re able to comb their hair more easily and brush it flat against their scalp.

Uncombable hair syndrome is a rare medical condition that affects babies and young children. The disorder changes the shape of the hair shaft, causing the hair to stick up from the scalp. Parents may find it difficult or impossible to comb out their child's hair.

In most cases, the condition goes away during puberty. In the meantime, parents should practice gentle hair-care techniques and talk to a dermatologist if they have concerns.

MedlinePlus. Uncombable hair syndrome.

National Organization for Rare Disorders. Uncombable hair syndrome.

Ramot Y, Zlotogorski A, Molho-Pessach V. Spontaneous quick resolution of uncombable hair syndrome-like disease. Skin Appendage Disord. 2019;5(3):162-164. doi:10.1159/000493649

Dermatology Advisor. Uncombable hair syndrome (pili trianguli et canaliculi, spun-glass hair, cheuveux incoiffables).

National Institute of Dental and Craniofacial Research. Ectodermal dysplasia.

National Center for Advancing Translational Sciences - Genetic and Rare Diseases Information Centers. Angel-shaped phalangoepiphyseal dysplasia.

National Center for Advancing Translational Sciences - Genetic and Rare Diseases Information Center. Bork Stender Schmidt syndrome.

National Center for Advancing Translational Sciences - Genetic and Rare Diseases Information Center. Uncombable hair syndrome.

Dermatology Times. Uncombable hair syndrome: how to identify and help children with this rare disorder.

By Laura DorwartLaura Dorwart is a health journalist with a focus on mental health, pregnancy-related conditions, and disability rights. Her writing has been published in VICE, SELF, The New York Times, The Guardian, and many more.

Ectodermal dysplasias Angel-shaped phalangoepiphyseal dysplasia Bork Stender Schmidt syndrome